Although many regimens for the acne therapy were proposed and were used upto date, there is, no ideal choice of treatment.
Since a certain relationship between the vitamin A and some dermatoses accompanied with dyskeratoses had been pro 3osed by Harris in 1932. many studies have been -reported for the acne treatment with vitamin A topical or oral administration. (Straumf ford 193, Lynch & Cook 1947, Anderson & Stokoe 1963).
In 1969, Kligman observed the peeling effect of vitamin A acid (VAA), a metabolite of vitamin A, on the human skin and he experienced very good effect of VAA topical application on acne patients.
Thereafter, many authors studied about the VAA and reported the excellent effect on acne (McGiils et al. 1971, Mills & Plewig 1972, Juhlin 1975). Moreover, in 1976, Kim & Lee observed similar results with the authors mentioned above in its cure rate and side effects.
In contrast to their high cure rate in those studies, however, its untoward side effects were frequently elicited with severe intensity.
So, author studied the effectiveness and side effects of VAAD which was changed in its chemical structure to diminish the side effects of VAA.
Thirty-seven patients (M:F=4:33) were studied, and the results obtained were as follows.
1. The total number of lesions decreased significantly from third week and decreased by half in 4th. week.
2. The number of closed comedones decreased significantly from second week but the number of open comedones temporarily increased in 1st. week and decreased thereafter.
3. pustules and papules continually decreased but new pustule formation developed in 3 patients and also disappeared in 4 weeks of treatment.
4. Allergic contact -dermatitis was. developed in 1 patient among 37 ? patients in 4th. week.
5. There were some undesirable side effects of sealing,´ pruritus, burning sensa-tion in about 80% respectively, but its intensity was mild or moderate, and fissure, edema and exudation which appeared in VAA treatment were not ob-served. only a few patients complained tightness, erythema and pain.
In comparison with VAA, the duration of treatment with VAAD was delayed
about 1-2 weeks and the effectiveness in acne therapy with VAAD was almost eq-ual to VAA therapy, and the side effects were markedly diminished.
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